Structure (WP Groups)
Meet the Work Packages
WP1
Multiomics ACS signatures discovery
chair Paolo Magni (UMIL)
vice-chair Iva Perović Blagojević
Objectives
- to build cohort of patients with ACS for discovery phase;
- to follow-up patients for MACE;
- to prepare samples for multiomics analysis,
- to perform targeted genomics, transcriptomics, proteomics and metabolomics;
- to prepare obtained data for integration in WP2.
Tasks
- Task 1.1 Building discovery cohort
- Task 1.2 Targeted genomics
- Task 1.3 Transcriptomics
- Task 1.4 Proteomics
- Task 1.5 Metabolomics
Deliverables
- D1.1 Discovery cohort data base
- D1.2 Report of ACS specific molecular signatures
- D1.3 Report on the follow-up of discovery cohort
- D1.4 Report of MACE specific molecular signatures
WP2
Development of multimarker models for better diagnosis of ACS and prediction of MACE using ML/AIbased approaches
chair Marco Chierici (FBK)
vice-chair Steven Watterson
Objectives
- to analyze individual genomic, transcriptomic, proteomic and metabolomic data specific for STEMI, NSTEMI and UAP,
- to use ML/AI for multiomics data integration,
- to identify multidimensional molecular signatures that spans across genomic, transcriptomic, proteomic and metabolomic specific for STEMI, NSTEMI, UAP,
- to identify best candidates for multimarker diagnostic models,
- to build multimarker diagnostic models.
Tasks
- Task 2.1 Integration of individual genomic, transcriptomic, proteomic and metabolomic data.
- Task 2.2 Identification of specific molecular signature
- Task 2.3 Development of preliminary multimarker models for diagnosis of ACS
- Task 2.4 Development of preliminary multimarker models for prediction of MACE
Deliverables
- D2.1 List of ACS specific molecular signatures
- D2.2 List of multi-marker models for ACS
- D2.3 List of multimarker models for MACE
WP3
Multimarker models validation
chair IRCCSMM Alberico Catapano
vice-chair Giacinto Guercilena (BSN)
Objectives
- to build validation cohorts,
- to validate genomic, transcriptomic, proteomic and metabolomic markers from the developed multi marker models for diagnosis of ACS,
- to validate genomic, transcriptomic, proteomic and metabolomic markers from the developed multi-marker models for prognosis of MACE.
Tasks
- Task 3.1 Validation cohorts
- Task 3.2 Validation of genomic markers
- Task 3.3 Validation of transcriptomic markers
- Task 3.4 Validation of proteomic markers
- Task 3.5 Validation of metabolomic markers
- Task 3.6 Data integration and statistical analysis
Deliverables
- D3.1 Validation cohort data base
- D3.2 Report on the follow-up of validation cohort
- D3.3 Validation report
- D3.4 Data integration report
- D3.5 Multimarker models
WP4
Standard operative procedures
chair Christos Tsatsanis (UOC)
vice-chair Maria Vinaixa Crevillent
Objectives
- to establish study protocols regarding patients recruitment, sample collection timing, follow-up parameters,
- to define the best sample type for particular analysis,
- to establish pre-analytical, analytical and post-analytical procedures including data curation and reporting,
- to evaluate data security and personal information security approaches,
- to standardize data integration and bioinformatics protocols.
Tasks
- Task 4.1 Standardization of protocol for patients recruitment and sample collection
- Task 4.2 Pre-analytical phase standardization
- Task 4.3 Analytical phase standardization
- Task 4.4. ML/AI and bioinformatics algorithm standardization
Deliverables
- D4.1 Study protocol
- D4.2 SOP for pre-analytical phase
- D4.3 SOP for analytical phase
- D4.4 SOP for ML/AI and bioinformatics
WP5
Scientists capacity building
chair Miron Sopic (PhUOB)
vice-chair Maria Vinaixa Crevillent | Anca Gafencu | Nuria Amigò
Tasks
- Task 5.1 Secondment programme
- Task 5.2 Networking events for knowledge transfer and reintegration
- Task 5.3 Webinar
- Task 5.4 Practical training
WP6
Dissemination
chair Nuria Amigò (BT)
vice-chair Jelena Munjas
Objectives
- to promote concepts of personalize and precise medicine in the field of CVD with focus on prevention, diagnosis and treatment,
- to promote standardization of methodological procedures in order to get valid markers of high clinical utility,
- to promote intersectoral and international exchange programs,
- to promote development of entrepreneurial skills in academic surroundings.
- to increase visibility and recognition of consortium’s researchers on national and international levels through congress, conferences and scientific papers published in open access journals relevant to the field.
Tasks
- Task 6.1 Social media and broadcasting media dissemination
- Task 6.2 Communication and public engagement
- Task 6.3 Dissemination through network events
- Task 6.4 Dissemination through publishing of scientific papers
Deliverables
- D6.1 Plan for dissemination and exloitation including communication activities
WP7
Project management
chair Paolo Magni
vice-chair Miron Sopic
project manager associate Sandra Vladimirov
Objectives
- to create the necessary governance structure for effective project focus and management,
- to coordinate and interface with the different management bodies (internal and external) and the European Commission,
- to manage and monitor the progress of secondments and implementation of the work in accordance to the timing, resources and budget,
- to ensure effective communication and collaboration between all project partners through the continuous exchange of information.
Tasks
- Task 7.1 Implementation of project management, governance, organization and decision-making procedures
- Task 7.2 General management and daily coordination
- Task 7.3 Administrative and financial management
- Task 7.4 Progress monitoring and periodic reporting
- Task 7.5 Data and IPR management
- Task 7.6 Risk management
Deliverables
- D7.1 Data management plan
- D7.2 Mid-term meeting
- D7.3 Progress Report
WP8
Ethics requirements
chair Paolo Magni
vice-chair Miron Sopic
Deliverables
- D8.1 OEI – Requirement No. 1
- D8.2 OEI – Requirement No. 2
- D8.3 OEI – Requirement No. 3